172. Evaluation of Retro-Aldol vs Retro-Carbonyl-Ene Mechanistic Pathways in a Complexity Generating C–C Bond Fragmentation

Ana S. Bulger, Daniel W. Turner, Qingyang Zhou, K. N. Houk, Neil K. Garg. Org. Lett. 2024, Manuscript Accepted.



163. Facile Synthesis of 2-Aza-9,10-diphenylanthracene and the Effect of Precise Nitrogen Atom Incorporation on OLED Emitters Performance

Evan R. Darzi, Dane A. Stanfield, Luca McDermott, Andrew V. Kelleghan, Benjamin J. Schwartz, and Neil K. Garg. Mater. Adv. 2023, 4, 3351–3355.


162. Cyclic Allene Approach to the Manzamine Alkaloid Keramaphidin B

Milauni M. Mehta, Jordan A. M. Gonzalez, James L. Bachman, and Neil K. Garg. Org. Lett. 2023, 25, 5553–5557.


161. Total Synthesis of Phenanthroindolizidines Using Strained Azacyclic Alkynes

Katie A. Spence, Marie Hoffmann, and Neil K. Garg. Org. Lett. 2023, 25, 5044–5048.


159. Catalyst-Controlled Annulations of Strained Cyclic Allenes with π-Allylpalladium Complexes

Dominick C. Witkowski, Matthew S. McVeigh, Georgia M. Scherer, Sarah M. Anthony, and Neil K. Garg. J. Am. Chem. Soc. 2023, 145, 10491–10496.


158. Strain-Promoted Reactions of 1,2,3-Cyclohexatriene and Its Derivatives

Andrew V. Kelleghan,† Ana S. Bulger,† Dominick C. Witkowski, and Neil K. Garg. Nature 2023, 618, 748–754.


157. Total Synthesis of Lissodendoric Acid A via Stereospecific Trapping of a Strained Cyclic Allene

Francesca M. Ippoliti,† Nathan J. Adamson,† Laura G. Wonilowicz, Daniel J. Nasrallah, Evan R. Darzi, Joyann S. Donaldson, and Neil K. Garg. Science 2023, 379, 261–265.

151. Merging Metals and Strained Intermediates

Katie A. Spence,† Arismel Tena Meza,† and Neil K. Garg. Chem Catalysis 2022, 2, 1870–1879.

149. π-Extension of heterocycles via a Pd-catalyzed heterocyclic aryne annulation: π-extended donors for TADF emitters

Katie A. Spence,† Jason V. Chari,† Mattia Di Niro, Robert B. Susick, Narcisse Ukwitegetse, Peter I. Djurovich, Mark E. Thompson, and Neil K. Garg. Chem. Sci. 2022, 13, 5884–5892.

146. Interception of 1,2-Cyclohexadiene with TEMPO Radical

Matthew S. McVeigh and Neil K. Garg. Tetrahedron Lett. 2021, 87, 153539–153543

144. Synthesis of Phenanthridinones via the Palladium-Catalyzed Annulation of Benzyne

Dominick C. Witkowski, Luca McDermott, and Neil K. Garg. Org. Synth. 2022, 99, 159–173.

141. Cycloaddition Cascades of Strained Alkynes and Oxadiazinones

Melissa Ramirez, † Evan Darzi, † Joyann Donaldson, Kendall N. Houk, Neil K. Garg. Angew. Chem., Int. Ed. 2021, 60, 18201–18208.

139. Palladium-Catalyzed Annulations of Strained Cyclic Allenes

Andrew V. Kelleghan, Dominick C. Witkowski, Matthew S. McVeigh, Neil K. Garg. J. Am. Chem. Soc. 2021, 143, 25, 9338–9342.

138. A Platform for On-the-Complex Annulation Reactions with Transient Aryne Intermediates

Jason V. Chari,† Katie A. Spence,† Robert B. Susick, and Neil K. Garg. Nat. Commun. 2021, 12, 3706.

137. Total Synthesis of (−)-Strictosidine and Interception of Aryne Natural Product Derivatives “Strictosidyne” and “Strictosamidyne”

Sarah M. Anthony,† Veronica Tona,† Yike Zou,† Lucas A. Morrill, John M. Billingsley, Megan Lim, Yi Tang,* K. N. Houk,* Neil K. Garg* J. Am. Chem. Soc. 2021, 143, 10, 7471–7479.

136. Origins of Endo Selectivity in Diels–Alder Reactions of Cyclic Allene Dienophiles

Melissa Ramirez, Dennis Svatunek, Fang Liu, Neil K. Garg, and K. N. Houk. Angew. Chem., Int. Ed. 2021, 60, 14989–14997.

128. Intercepting Fleeting Cyclic Allenes with Asymmetric Nickel Catalysis

Michael M. Yamano,† Andrew V. Kelleghan,† Qianzhen Shao,† Maude Giroud, Bryan J. Simmons, Bo Li, Shuming Chen, K. N. Houk, and Neil K. Garg. Nature 2020, 586, 242–247.

123. Silyl Tosylate Precursors to Cyclohexyne, 1,2-Cyclohexadiene, and 1,2-Cycloheptadiene

Matthew S. McVeigh, Andrew V. Kelleghan, Michael M. Yamano, Rachel R. Knapp, and Neil K. Garg. Org. Lett. 202022, 4500–4504. 

112. Synthesis of Triphenylene via the Palladium-catalyzed Annulation of Benzyne

Katie A. Spence, Milauni M. Mehta, and Neil K. Garg. Org. Synth. 2022, 99, 174–189.

108. Cyclic Alkyne Approach to Heteroatom-Containing Polycyclic Aromatic Hydrocarbon Scaffolds

Evan R. Darzi, Joyann S. Barber, and Neil K. Garg. Angew. Chem., Int. Ed. 2019, 58, 9419–9424.

106. Cycloadditions of Oxacyclic Allenes and a Catalytic Asymmetric Entryway to Enantioenriched Cyclic Allenes

Michael M. Yamano, Rachel R. Knapp, Aurapat Ngamnithiporn, Melissa Ramirez, Kendall N. Houk,* Brian M. Stoltz,* and Neil K. Garg. Angew. Chem., Int. Ed. 2019, 58, 5653–5657.

105. A Concise Approach to Cyclohexyne and 1,2-Cyclohexadiene Precursors

Jason Chari,† Francesca Ippoliti,† and Neil K. Garg. J. Org. Chem. 2019, 84, 3652–3655.

97. Diels–Alder Cycloadditions of Strained Azacyclic Allenes

Joyann S. Barber,† Michael M. Yamano,† Melissa Ramirez, Evan R. Darzi, Rachel R. Knapp, Fang Liu, K. N. Houk, and Neil K. Garg. Nat. Chem. 201810, 953–960.

94. Arynes and Cyclic Alkynes as Synthetic Building Blocks for Stereodefined Quaternary Centers

Elias Picazo,† Sarah M. Anthony,† Maude Giroud, Adam Simon, Margeaux A. Miller, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2018140, 7605–7610.

86. Conjugated Trimeric Scaffolds Accessible from Indolyne Cyclotrimerizations: Synthesis, Structures, and Electronic Properties

Janice B. Lin, Tejas K. Shah, Adam E. Goetz, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc2017139, 10447–10455.

84. Total Synthesis of (–)-Tubingensin B Enabled by the Strategic Use of an Aryne Cyclization

Michael A. Corsello,† Junyong Kim,† and Neil K. Garg. Nat. Chem20179, 944–949.

74. Expanding the ROMP Toolbox: Synthesis of Air-Stable Benzonorbornadiene Polymers by Aryne Chemistry

Jose M. Medina, Jeong Hoon Ko, Heather D. Maynard, and Neil K. Garg. Macromolecules 201750, 580–586.

70. Quantification of the Electrophilicity of Benzyne and Related Intermediates

Noah F. Fine Nathel,† Lucas A. Morrill,† Herbert Mayr, and Neil K. Garg. J. Am. Chem. Soc2016138, 10402–10405

65. Expanding the Strained Alkyne Toolbox: Generation and Utility of Oxygen-Containing Strained Alkynes

Tejas K. Shah,† Jose M. Medina,† and Neil K. Garg. J. Am. Chem. Soc2016138, 4948–4954

63. Synthetic Studies Pertaining to the 2,3-Pyridyne and 4,5-Pyrimidyne

Jose M. Medina, Moritz K. Jackl, Robert B. Susick, and Neil K. Garg. Tetrahedron 201672, 3629–3634

62. Nitrone Cycloadditions of 1,2-Cyclohexadiene

Joyann S. Barber, Evan D. Styduhar, Hung V. Pham, Travis C. McMahon, K. N. Houk, and Neil K. Garg.  J. Am. Chem. Soc2016138, 2512–2515

55. Generation and Regioselective Trapping of a 3,4-Piperidyne for the Synthesis of Functionalized Heterocycles

Travis C. McMahon,† Jose M. Medina,† Yun-Fang Yang, Bryan J. Simmons, K. N. Houk, and Neil K. Garg. 
J. Am. Chem. Soc. 2015137, 4082–4085

53. Computational Predictions of Substituted Benzyne and Indolyne Regioselectivities

Elias Picazo, K. N. Houk, and Neil K. Garg. Tetrahedron Lett. 201556, 3511–3514. (Special issue for Professor Harry Wasserman)

51. Pyridynes and Indolynes as Building Blocks for Functionalized Heterocycles and Natural Products

Adam E. Goetz, Tejas K. Shah and Neil K. Garg. Chem. Commun. 201551, 34–45. (Featured Article)

50. The Role of Aryne Distortions, Steric Effects, and Charges on Regioselectivities in Aryne Reactions

Jose M. Medina,† Joel L. Mackey,† Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc2014136, 15798–15805

49. Total Synthesis of (–)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy

Nicholas A. Weires,† Evan D. Styduhar,† Emma L. Baker, and Neil K. Garg. J. Am. Chem. Soc2014136, 14710–14713

48. Cycloadditions of Cyclohexynes and Cyclopentyne

Jose M. Medina,† Travis C. McMahon,† Gonzalo Jiménez-Osés, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc2014136, 14706–14709

43. Concise Enantiospecific Total Synthesis of Tubingensin A

Adam E. Goetz,† Amanda L. Silberstein,† Michael A. Corsello, and Neil K. Garg. J. Am. Chem. Soc. 2014136, 3036–3039

42. Total Syntheses of Indolactam Alkaloids (–)-Indolactam V, (–)-Pendolmycin, (–)-Lyngbyatoxin A, and (–)-Teleocidin A-2

Noah F. Fine Nathel,† Tejas K. Shah,† Sarah M. Bronner, and Neil. K. Garg. Chem. Sci. 20145, 2184–2190

41. Enabling the Use of Heterocyclic Arynes in Chemical Synthesis

Adam E. Goetz and Neil K. Garg. J. Org. Chem. 201479, 846–851

39. Enantiospecific Total Synthesis of N-Methylwelwitindolinone D Isonitrile

Evan D. Styduhar, Alexander D. Huters, Nicholas A. Weires, and Neil K. Garg. Angew. Chem. Int. Ed. 201352, 12422–12425

34. Regioselective Reactions of 3,4-Pyridynes Enabled by the Aryne Distortion Model

Adam E. Goetz and Neil K. Garg. Nat. Chem. 20135, 54–60

30. Steric Effects Compete with Aryne Distortion to Control Regioselectivities of Nucleophilic Additions to 3-Silylarynes

Sarah M. Bronner, Joel L. Mackey, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2012134, 13966–13969

26. Total Syntheses of the Elusive Welwitindolinones with Bicyclo[4.3.1]cores

Alexander D. Huters, Evan D. Styduhar, and Neil K. Garg. Angew. Chem. Int. Ed. 201251, 3758–3765

25. An Efficient Computational Model to Predict the Synthetic Utility of Heterocyclic Arynes

Adam E. Goetz, Sarah M. Bronner, Jordan D. Cisneros, Joshua M. Melamed, Robert S. Paton, K. N. Houk, and Neil K. Garg. Angew. Chem. Int. Ed. 201251, 2758–2762

24. Total Synthesis of Oxidized Welwitindolinones and (–)-N-Methylwelwitindolinone C Isonitrile

Kyle W. Quasdorf, Alexander D. Huters, Michael W. Lodewyk, Dean J. Tantillo, and Neil K. Garg. J. Am. Chem. Soc. 2012134, 1396–1399

22. Total Synthesis of (–)-N-Methylwelwitindolinone C Isothiocyanate

Alexander D. Huters, Kyle W. Quasdorf, Evan D. Styduhar, and Neil K. Garg. J. Am. Chem. Soc2011133, 15797–15799

21. Understanding and Modulating Indolyne Regioselectivities

Sarah M. Bronner, Adam E. Goetz, and Neil K. Garg. Synlett 201118, 2599–2604. (invited SYNPACTS article)

16. Overturning Indolyne Regioselectivities and Synthesis of Indolactam V

Sarah M. Bronner, Adam E. Goetz, and Neil K. Garg. J. Am. Chem. Soc2011133, 3832–3835

12. Indoles and Indolizidines in Heterocycles in Natural Product Synthesis

Sarah M. Bronner, G-Yoon J. Im, and Neil K. Garg; K. C. Majumdar and S. K. Chattopadhyay, Eds.; Wiley–VCH, 2011

11. Indolyne Experimental and Computational Studies: Synthetic Applications and Origins of Selectivities of Nucleophilic Additions

G-Yoon J. Im, Sarah M. Bronner, Adam E. Goetz, Robert S. Paton, Paul H.-Y. Cheong, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc2010132, 17933–17944

7. Indolyne and Aryne Distortions and Nucleophilic Regioselectivities

Paul H.-Y. Cheong, Robert S. Paton, Sarah M. Bronner, G-Yoon J. Im, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2010132, 1267–1269.

5. Efficient Synthesis of 2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate: A Versatile Precursor to o-Benzyne

Sarah M. Bronner and Neil K. Garg. J. Org. Chem200974, 8842–8843

3. Concise Synthesis of the Bicyclic Scaffold of N-Methylwelwitindolinone C Isothiocyanate via an Indolyne Cyclization

Xia Tian, Alexander D. Huters, Colin J. Douglas, and Neil K. Garg. Org. Lett. 200911, 2349–2351

2. Indolynes as Electrophilic Indole Surrogates: Fundamental Reactivity and Synthetic Applications

Sarah M. Bronner, Kevin B. Bahnck, and Neil K. Garg. Org. Lett200911, 1007–1010